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Heinz Lohrer and Ludger Gerdesmeyer
2014
Shock Wave Therapy in Practice: Multidisciplinary Medical Applications
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C. D'Agostino, P. Romeo, E. Amelio, V. Sansone
Ultrasound in medicine biology, 37 (9), 2011, pp. 1452-1456
Effectiveness of ESWT in the Treatment of Kienböck's Disease
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E. Tinazzi, E. Amelio, E. Marangoni, C. Guerra, A. Puccetti, O. M. Codella, S. Simeoni, E. Cavalieri, M. Montagnana, R. Adani, R. Corrocher, C. Lunardi
Rheumatology International, 31 (5), 2011, pp. 651-656
Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study
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E. Amelio, P. Manganotti
Journal of Rehabilitation Medicine, 42 (4), 2010, pp. 339-343(5)
Effect of shock wave stimulation on hypertonic plantar flexor muscles in patients with cerebral palsy: A placebo-controlled study
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C. Trompetto, L. Avanzino, M. Bove, L. Marinelli, L. Molfetta, R. Trentini, G. Abbruzzese
European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies, 16 (4), 2009, pp. 517-521
External shock waves therapy in dystonia: preliminary results
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E. Amelio MD, P. Manganotti
Proceedings of 7th International Symposium on Experimental Spinal Cord Repair and Regeneration, 2009
Effect of Extracorporeal Shock Wave Therapy on Spastic Hypertonia
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H. Lohse-Busch, M. Kraemer, U. Reime
Journal of Neurology, 253 (2), Sixteenth Meeting of the European Neurological Society, 2006
Extracorporeal shock waves in the rehabilitation of children with cerebral palsy
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A. Aicher, C. Heeschen, K. Sasaki, C. Urbich, A. M. Zeiher, S. Dimmeler
Circulation - Journal of the American Heart Association, 114, 2006, pp. 2823-2830
Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia
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Background - Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth factor is crucial for the recruitment of circulating endothelial progenitor cells (EPCs) during acute ischemia. In chronic ischemia, however, expression of these chemoattractants is less pronounced, which results in insufficient EPC recruitment into the target tissue. Therefore, we investigated the effect of targeted extracorporeal shock wave (SW) application in order to facilitate EPC recruitment into nonischemic and chronic ischemic tissue. Methods and Results - Hind limb adductor muscles of nude rats were treated with 500, 1000, and 2000 impulses of focused low-energy SW (flux density level: 0.05 mJ/mm2). Twenty-four hours later, mRNA expression of the chemoattractant stromal cell-derived factor 1 was significantly increased with 1000 impulses (stromal cell-derived factor 1/GAPDH: 0.95±0.09) and 2000 impulses (stromal cell–derived factor 1/GAPDH: 1.17±0.24; both P<0.05 versus untreated). Histologically, the number of vascular endothelial growth factor-positive endothelial cells per myocyte was significantly increased with 2000 impulses (0.24±0.05 versus 0.09±0.02; P<0.01). This preconditioning effect resulted in significantly enhanced recruitment and homing of EPCs that were intravenously infused 24 hours after SW treatment (P<0.05). In a rat model of chronic hind limb ischemia, SW-facilitated EPC treatment resulted in a significant increase in relative blood flow recovery as assessed by laser Doppler imaging (P<0.05). Conclusions - Preconditioning of both nonischemic and chronic ischemic tissue with low-energy SW improves recruitment of circulating EPCs via enhanced expression of chemoattractant factors. Thus, SW-facilitated cell therapy may improve the efficacy of EPC treatment in patients with chronic ischemia.

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A. A. Khattab, B. Brodersen, D. Schuermann-Kuchenbrandt, H. Beurich, R. Tölg, V. Geist, T. Schäfer, G. Richardt
International Journal of Cardiology, 121 (1), 2006, pp. 84-5
Extracorporeal cardiac shock wave therapy: First experience in the everyday practice for treatment of chronic refractory angina pectoris
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E. Amelio, P. Manganotti
Journal of Neurology, 253 (2), Sixteenth Meeting of the European Neurological Society, 2006
Effect of shock-wave therapy on spastic equinus foot in patients affected by cerebral palsy
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P. Manganotti, E. Amelio
Stroke - Journal of the American Heart Association, 36 (9), 2005, pp. 1967-1971
Long-Term Effect of Shock Wave Therapy on Upper Limb Hypertonia in Patients Affected by Stroke
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R. Meirer, F.S. Kamelger, H. Piza-Katzer
Burns, 31 (7), 2005, pp. 921-922
Shock wave therapy: An innovative treatment method for partial thickness burns
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A. R. Ciampa, A. Carcereri de Prati, E. Amelio, E. Cavalieri, T. Persichini, M. Colasanti, G. Musci, E. Marlinghaus, H. Suzuki, S. Mariotto.
FEBS Letters, 579 (30), 2005, pp. 6839-6845
Nitric Oxide mediates anti-inflammatory action of extracorporeal shock waves
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Ching-Jen Wang, Feng-Sheng Wang, Chung-Cheng Huang, Kuender D. Yang, Lin-Hsiu Weng and Hsuan-Ying Huang
Journal of Bone & Joint Surgery (JBJS), 87 (11), 2005, pp. 2380-2387
Treatment for Osteonecrosis of the Femoral Head: Comparison of Extracorporeal Shock Waves with Core Decompression and Bone-Grafting
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Background: There is continuing controversy regarding the optimal treatment for patients with symptomatic early-stage osteonecrosis of the femoral head. We compared the results of noninvasive treatment with extracorporeal shock waves with those of core decompression and bone-grafting in similar groups of patients. Methods: Patients with stage-I, II, or III osteonecrosis were randomly assigned to be treated either with shock waves or with core decompression and nonvascularized fibular grafting. The shock-wave group consisted of twenty-three patients (twenty-nine hips), and the surgical group consisted of twenty-five patients (twenty-eight hips). The patients in the two groups had similar demographic characteristics, duration and stage of disease, and duration of follow-up. The patients in the shock-wave group received a single treatment with 6000 impulses of shock waves at 28 kV to the affected hip. The evaluation parameters included clinical assessment of pain with a visual analog pain scale, Harris hip scores, and an assessment of activities of daily living and work capacity. Radiographic assessment was performed with serial plain radiographs and magnetic resonance imaging. Results: Before treatment, the two groups had similar pain and Harris hip scores. At an average of twenty-five months after treatment, the pain and Harris hip scores in the shock-wave group were significantly improved compared with the pretreatment scores (p < 0.001). In this group, 79% of the hips were improved, 10% were unchanged, and 10% were worse. Of the hips treated with a nonvascularized fibular graft, 29% were improved, 36% were unchanged, and 36% were worse. In the shock-wave group, imaging studies showed regression of five of the thirteen lesions that had been designated as stage I or II before treatment and no regression of a stage-III lesion. Two stage-II and two stage-III lesions progressed. In the surgical group, four lesions regressed and fifteen (of the nineteen graded as stage I or II) progressed. The remaining nine lesions were unchanged. Conclusions: Extracorporeal shock-wave treatment appeared to be more effective than core decompression and nonvascularized fibular grafting in patients with early-stage osteonecrosis of the femoral head. Long-term results are needed to determine whether the effect of this novel method of treatment for osteonecrosis of the femoral head endures.

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S. Mariotto, E. Cavalieri, E. Amelio, A. R. Ciampa, A. Carcereri de Prati, E. Marlinghaus, S. Russo, H. Suzuki
Nitric Oxide, 12, 2005, pp. 89-96
From lithotripsy to anti-inflammatory action by NO production
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T. Nishida, H. Shimokawa, K. Oi, H. Tatewaki, T. Uwatoku, K. Abe, Y. Matsumoto, N. Kajihara, M. Eto, T. Matsuda, H. Yasui, A. Takeshita, K. Sunagawa
Circulation, 110 (19), 2004, pp. 3055-3061
Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo
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E. Amelio and P. Manganotti
Proceedings of 9th Congress of the International Federation of Societies for Surgery the Hand, 2004, pp. 535-540
Effect of Shock Wave Therapy in Patients Affected by Stroke with Upper Limb Spasticity: Neurophysiologic and Clinical Study
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H. Suzuki, E. Amelio, E. Cavalieri, S. Mariotto, O. Galasso, S. Russo
Abstract of 6th Congress of the International Society of Musculoskeletal Shockwave Therapy (ISMST), 2003
Effect of Shock Wave on the Catalytic Activity of Endothelial Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells.
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E. Amelio, P. Manganotti, O. Galasso and L. Cugola
The Journal of Hand Surgery (JHS), 28 (1), 2003, pp. 61
Neurophysiologic Study on Shock Wave Therapy in Upper Limb Spasticity
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G. Gotte, E. Amelio, S. Russo, E. Marlinghaus, G. Musci, H. Suzuki
FEBS Letters, 520 (1-3), 2002, pp. 153-155
Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment
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